Oswego's undergraduate programs allow students to explore their interests from A (accounting) to Z (zoology). Oswego offers more than 60 academic majors as well as 10 cooperative degree programs where students complete joint degrees with other institutions. Students can also complete a secondary concentration in nearly as many academic minors.

Along with their major/minor program coursework, students are required to complete a set of coursework in General Education, a program that provides the foundation for a liberal arts education and opens doors to new interests as well as potential pathways to success.