There are a number of research centers on the SUNY Oswego campus to support collaboration between faculty and as major instrumentation facilities.

• The Center for Neurobehavioral Effects of Environmental Toxins conducts extensive and valuable research on how toxic chemicals affect humans and animals.
• The Environmental Research Center is affiliated with the Department of Chemistry and specializes in the analysis of pollutants in our environment.
• The Molecular Biology and Biochemistry Center is a teaching and research facility that consists of several laboratories and offices in Snygg Hall, including the mass spectrometry and proteomics center funded by the National Science Foundation in 2004.
• The Mass Spectrometry and Proteomics Center at SUNY-Oswego is a resource for students and faculty to analyze a wide variety of samples using 2 dimensional electrophoresis and Matrix Assisted Laser Desorption Ionization - Time of Flight Mass Spectrometry (MALDI-TOF MS).
• The Center for Accounting Research and Education (CARE) supports faculty research, diversity initiatives, continuing professional education, student education, and community outreach as well as social responsibility and ethical training in accounting.
• The Lake-Effect Storm Prediction and Research Center (LESPaRC) at SUNY Oswego forecasts hazardous winter weather for several clients (e.g., school districts) across Central New York and conducts research regarding lake-effect storms to improve our understanding and accuracy at predicting these events.